Showing posts with label glycation. Show all posts
Showing posts with label glycation. Show all posts

Tuesday, May 20, 2014

Study: Females who ate most liquid sucrose and liquid fructose faced above-average chance of dying

This recently published research study re-enforces my previous assumptions that high intake of glucose can lead to higher effects of glycation(destruction of the endothelium and accumulation of plaque) and therefore lead to higher risks of ischemic heart disease. This study finds that glucose and fructose consumed in the liquid form can more readily lead to increased risks of dying particularly from cardiovascular disease.

Study: High Fructose Intake Linked to Slightly Higher Risk of Death
http://www.womenshealthmag.com/nutrition/high-fructose

"those who consumed lots of liquid sugar—from sodas, sports drinks, juices, etc.—had higher odds of dying of any cause (from cardiovascular disease, in particular). Why? It could be because sugars from beverages are rapidly absorbed, resulting in significant blood-sugar spikes, the scientists say."

"While this study just proved association, not causation, scientists do have a theory: Fructose produces "advanced glycation end-products," or AGEs, which may damage the walls of your arteries, encourage bad cholesterol to hang around"

"You don't, of course, have to give up fruit, which is a staple of any well-balanced diet. But you may want to cut back on your intake of other sources of fructose: fruit juices, soft drinks, preserves, applesauce, dried fruit, and candies."

5 Smart Steps to Cut Down On Sugar
http://time.com/94573/5-smart-steps-to-cut-down-on-sugar/

Friday, March 14, 2014

Cholesterol Level and Saturated Fats are Not the Real Factors of Heart Disease — Glycation is One of The Main Factors

The theory held by many people including doctors that LDL cholesterol and saturated fat can cause heart disease is still a theory not yet proven to be true.

Plaque is known to constrict blood vessels that lead to heart disease. However, the smooth endothelium(one-cell thick lining of blood vessels) has to first be damaged in order for plaque to accumulate.

The low-density lipoprotein aka LDL(that carries cholesterol and lipids/fats) has to first enter damaged areas of the smooth endothelium(one-cell thick lining of blood vessels) in order to create plaque.

Cholesterol is found inside the lipoproteins and cholesterol cannot simply attach to the smooth endothelium nor damage it, it is a mistaken false theory that many doctors and writers of health sites still follow. LDL is also not 'bad' and its particle size doesn't affect heart disease.

Cholesterol cannot simply attach to the smooth endothelium, and therefore is not a cause of heart disease.

http://www.heart.org/HEARTORG/Conditions/Cholesterol/WhyCholesterolMatters/Atherosclerosis_UCM_305564_Article.jsp
"Exactly how atherosclerosis begins or what causes it isn't known, but some theories have been proposed."

http://umm.edu/health/medical/altmed/condition/atherosclerosis
"No one knows the exact cause of atherosclerosis"

We have got cholesterol completely wrong
http://www.zoeharcombe.com/the-knowledge/we-have-got-cholesterol-completely-wrong/


Personal opinion:

Blood cholesterol level and saturated fat are actually not the real factors of heart disease. It is when the smooth endothelium(lining of the blood vessels) get damaged by factors such as glycation(destruction of protein fibers in blood vessels) that the low density lipoproteins aka LDL(that carries fat and cholesterol) get to enter the damaged area. The repeat of such endothelium damage and entering of the LDL eventually forms plaque that can constrict the blood vessels and can lead to heart disease. Other factors can also come from constriction of the blood vessels by things like polyphenols(olive oil). Other proinflammation factors can also weaken the blood vessels over time.

It is not cholesterol or saturated fat that leads to heart disease but the damage to the smooth lining of the blood vessels. Too much blood vessel 'scarring' is harmful. This is why it is important not to consume excessively on foods such as starches and sugar that are very high on the Glycermic Index, which can lead to glycation that can damage the lining of the blood vessels and set off the progression of heart disease.

People who still think that cholesterol level and saturated fat lead to heart disease are still not aware of the bigger picture of heart disease.

I realize that many researchers have not yet made such a conclusion perhaps they are not well-aware of the effects of glycation and other factors on the endothelium. Perhaps in future, this can be confirmed in lab studies. Maybe I will contact some researchers to offer them my opinion.

Deleterious effect of glycation on the ability of HDL to counteract the inhibitory effect of oxidized LDL on endothelium-dependent vasorelaxation.
http://www.ncbi.nlm.nih.gov/pubmed/23908137

Proinflammation: the key to arterial aging
http://www.ncbi.nlm.nih.gov/pubmed/24365513

Friday, March 7, 2014

Debunking the Grain Brain Diet — A Diet that Promotes Eating Lots of Fat and Meat

I heard of the recent best-seller diet book called Grain Brain by David Perlmutter, neurologist and president of the Perlmutter Health Center in Naples, Fla.

What Grain Is Doing To Your Brain
http://www.forbes.com/sites/nextavenue/2013/11/14/what-grain-is-doing-to-your-brain/

"all carbs, including highly touted whole grains, are devastating to our brains. He claims we must make major changes in our eating habits as a society to ward off terrifying increases in Alzheimer’s disease and dementia rates.

And yet Perlmutter argues that his recommendations are not radical at all. In fact, he says, his suggested menu adheres more closely to the way mankind has eaten for most of human history.

What’s deviant, he insists, is our modern diet. Dementia, chronic headaches, depression, epilepsy and other contemporary scourges are not in our genes, he claims. “It’s in the food you eat,”

"Perlmutter says we need to return to the eating habits of early man, a diet generally thought to be about 75% fat and 5% carbs. The average U.S. diet today features about 60% carbs and 20% fat."

"Human genes, he says, have evolved over thousands of years to accommodate a high-fat, low-carb diet. But today we feed our bodies almost the opposite, with seemingly major effects on our brains. A Mayo Clinic study published earlier this year in the Journal of Alzheimer’s Disease found that people 70 and older with a high-carbohydrate diet face a risk of developing mild cognitive impairment 3.6 times higher than those who follow low-carb regimens. Those with the diets highest in sugar did not fare much better. However, subjects with the diets highest in fat were 42% less likely to face cognitive impairment than the participants whose diets were lowest in fat."


Here are my thoughts on the diet—

I checked out articles about the Grain Brain book and found the book to be quite biased with much fallacies about diet. I think the author suggested his diet of high fat and low carbs because the brain that is made up of 60% fat is more vulnerable to glycation damage on proteins(including blood veins) due to high blood glucose(from consuming high GI carbs) compared to other parts of the body that have more protein percentage to shield against glycation's protein damage.(view footnotes about glycation)

I also think that the earliest human species had to binge on fat because it was the most convenient source of calories because fat has 9 calories per gram compared to carb's and protein's 4 calories per gram. And they didn't know when their next meal would be coming so they had to binge efficient calories(from fat) as much as possible. Fat was also needed to keep bodies warm during cold winters.

So I don't think modern humans have to necessarily follow the eating habits of ancient humans. Modern people now have the luxury of eating more healthy foods and less of a need to binge on high calorie fat, and also are able to obtain good heating during cold winters so there is less of the need to require fat to keep the body warm.

Much modern advances in acquiring food and heating means that the human species can more easily adopt a vegan lifestyle in modern times compared to the past.

I feel that the author has committed the fallacy of thinking that the ancient diet is most natural and that modern man has to follow it. There is also the fallacy of thinking that carbs has to be drastically reduced just because the brain is more vulnerable to glycation's protein damage compared to other parts of the body.


Footnotes on Glycation

(Elle Magazine) Sugar and Aging: How to Fight Glycation
The relationship between sugar and fine lines can be sticky. Find out why!
http://www.elle.com/beauty/makeup-skin-care/sugar-aging-how-to-fight-glycation-614621

"The science is this: When you have sugar molecules in your system, they bombard the body's cells like a meteor ­shower—glomming onto fats and proteins in a process known as glycation. This forms advanced glycation end products (commonly shortened, appropriately, to AGEs), which cause protein fibers to become stiff and malformed."

"The proteins in skin most prone to glycation are the same ones that make a youthful complexion so plump and springy—collagen and elastin. When those proteins hook up with renegade sugars, they become discolored, weak, and less supple; this shows up on the skin's surface as wrinkles, sagginess, and a loss of radiance. The presence of AGEs also makes the complexion more vulnerable to bad-news assailants such as UV light and cigarette smoke. As New York–based dermatologist Cheryl Karcher, MD, puts it: "Number one, the glucose makes the cells abnormal; and number two, it creates free radicals. So you get a double whammy when it comes to aging."

"The external signs of glycation show up around the age of 30 or 35, when a perfect storm of built-up sun damage, environmental oxidative stress, hormonal changes, and the development of AGEs begins to result in, well, a-g-e. "When you're younger, your body has more resources to ward off damage, and you're producing more collagen," says New York– and Miami-based dermatologist Fredric Brandt, MD, who in 2007 was one of the first to launch an anti-aging skin-care line specifically addressing glycation. "When you reach a certain age, these sugar by-products begin to build up at the same time that your threshold for damage is getting lower."

Higher glucose levels associated with lower memory and reduced hippocampal microstructure
http://www.neurology.org/content/early/2013/10/23/01.wnl.0000435561.00234.ee.abstract
"Conclusions: Our results indicate that even in the absence of manifest type 2 diabetes mellitus or impaired glucose tolerance, chronically higher blood glucose levels exert a negative influence on cognition, possibly mediated by structural changes in learning-relevant brain areas."

Protecting Against Glycation and High Blood Sugar with Benfotiamine
http://www.lef.org/magazine/mag2008/apr2008_Protecting-Against-Glycation-High-Blood-Sugar-With-Benfotiamine_01.htm

Glycation and the Skin
http://www.skininc.com/skinscience/physiology/Glycation-and-the-Skin-230102271.html?page=2

Insulin and Its Metabolic Effects(2001)
Glycation
http://articles.mercola.com/sites/articles/archive/2001/07/14/insulin-part-one.aspx
"Everyone knows that oxygen causes damage, but unfortunately the press has not been as kind to publicize glycation. Glycation is the same as oxidation except substitute the word glucose. When you glycate something you combine it with glucose. Glucose combines with anything else really; it's a very sticky molecule.

Just take sugar on your fingers. It's very sticky. It sticks specifically to proteins. So the glycation of proteins is extremely important. If it sticks around a while it produces what are called advanced glycated end products (A.G.E.s).

That acronym is not an accident. If you can turn over, or re-manufacture, the protein that's good, and it increases the rate of protein turnover if you are lucky. Glycation damages the protein to the extent that white blood cells will come around and gobble it up and get rid of it, so then you have to produce more, putting more of a strain on your ability to repair and maintain your body.

That is the best alternative; the worst alternative is when those proteins get glycated that can't turn over very rapidly, like collagen, or like a protein that makes up nerve tissue. These proteins cannot be gotten rid of, so the protein accumulates, and the A.G.E.s accumulate and continue to damage.

That includes the collagen that makes up the matrix of your arteries. A.G.E.s are so bad that we know that there are receptors for A.G.E.s, hundreds of receptors, for every macrophage."

Sunday, March 2, 2014

6 of the Most Potent Anti-Aging Secrets to Thrive Much Further in Life

I have some personal recommendations for anti-aging since I haven't seen these being widely practiced around. I follow these recommendations myself to thrive at what I do in my own life as well as to maintain my youthfulness, and I would like to share these with everyone who also have such intention to thrive. They are all based on well-documented scientific studies.


Purple Foods for Anti-Aging

Purple and blue foods such as purple cabbages, eggplant, small red beans and berries contain anthocyanins good for anti-aging results. Even Mariah Carey takes purple foods 3 times a week. I don't recall seeing many people making purple smoothies, the popular type is still the one containing green vegetables that contain green chlorophyll.


Chinese Herbs for Anti-Aging and Resilience/Strength

2 of the most potent Chinese herbs are yellow astragalus(Huang Qi) and fleeceflower root(He Show Wu). Yellow astragalus is actually better than ginseng, it has been scientifically proven to be able to extend the telomerase at the end of chromosomes, extending the cells' expiry date and prolonging lifespan.

He Shou Wu has a strengthening effect from the introduction of the root's resilience into the body to increase its resilience/strength. It promotes faster healing during sickness, increases the body's resilience to physical stress endured in high and low intensity sports, as well as increase sexual function for men. It is useful for warming up the body during cold winters, and has been widely claimed to be able to restore hair loss and reverse premature greying of hair.

Common everyday vegetables in the supermarkets do not have as much resilience as such resilient plants that are trees and roots that can live hundreds of years. Eating such plants would therefore 'transfer' the plants' longevity and resilience into the human body. This is how such herbs actually work in order to improve the body's health and resilience/strength.


Negative Ions

Negative ions are found abundantly from water splashes such as waterfalls, beaches, fountains, the washing sink, the bathroom shower. It is also found in lemons. Negative ion generators can provide a constant flow of ions that has been scientifically demonstrated to improve brain function, prevent depression, prevent cancer and extend lifespan.

Negative Ions Create Positive Vibes
http://www.webmd.com/balance/features/negative-ions-create-positive-vibes

Science : The Power of The Negative Ions
http://www.youtube.com/watch?v=I66oE44rejQ


Distilled Water

Non-distilled tap water contains animal wastes from water-based animals such as fishes and frogs and therefore is not actually vegan if you think of it. Such non-distilled water also contains added chemicals such as chloride, fluoride and other unknown pollutants from the environment. I usually find a puddle of foul-smelling yellowish liquid at the bottom of my distiller after the water has been distilled away.

Water can only hold a certain amount of impurities and if it is not distilled, it would not have the full ability to hold on to the body's impurities to effectively flush them out of the system. If the impurities from non-distilled water is reduced from getting into the body, the body would contain less impurities and one doesn't have to consume as much water for hydration purposes. With less impurities and toxins entering the body from drinking distilled water, the body can function at a higher level, and not age as quickly.


Avoid Foods Cooked in Dry Heat and Oil

Meat and vegetables that are cooked in dry heat and oil create toxins that can age the body as well as contribute to illnesses such as cancer. For me to avoid the toxins, I rely mostly on boiled foods such as chickpeas and lentils.

The Hidden Toxins in Cooked Foods
http://americannutritionassociation.org/newsletter/hidden-toxins-cooked-foods

"Many may not be aware, however, of the toxins and carcinogens that exist when food is heated past a certain temperature or for a period of time"

"Cooked meat and fish contain heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs), both of which have been shown to be mutagenic and carcinogenic."

"Acrylamide is a carcinogen that is found in cigarettes, coffee, and many baked or fried foods, particularly breads, potato and corn products."

Chemicals in Meat Cooked at High Temperatures and Cancer Risk
http://www.cancer.gov/cancertopics/factsheet/Risk/cooked-meats

 
Choose Foods Low on the Glycermic Index

Foods that are high on the Glycermic Index can lead to excessive glycation that can age protein fibres such as skin, blood vessels and nerves. Common foods that are high on the Index include donuts, cakes, buns, white bread, sugary drinks, and candy etc

Even when eating foods that are low on the Glycermic Index, one also has to be aware of the Glycermic Load to ensure that there is no overloading of blood sugar in the blood by consuming too much food at once. The Glycermic Load can be effectively reduced by practicing grazing, which is done by dividing the number of large meals in a day into smaller meals.

Foods such as white rice(66) and potatoes(over 90) are high on the Glycermic Index. Alternatives such as brown rice(46) and chickpeas(28) are much lower on the Index.

Avoid consuming carbohydrates on its own but eat it with protein and fats. Consume vegetables first before consuming carbohydrates to reduce the speed of digestion. 

Taking too much low GI fruits at once such as binging on a large amounts of sweet juices and smoothies can still increase the sugar level in the blood to high levels. The key is to either eat fruits whole without juicing or limit juices and smoothies to smaller portions.

(Elle Magazine) Sugar and Aging: How to Fight Glycation
The relationship between sugar and fine lines can be sticky. Find out why!
http://www.elle.com/beauty/makeup-skin-care/sugar-aging-how-to-fight-glycation-614621

"The science is this: When you have sugar molecules in your system, they bombard the body's cells like a meteor ­shower—glomming onto fats and proteins in a process known as glycation. This forms advanced glycation end products (commonly shortened, appropriately, to AGEs), which cause protein fibers to become stiff and malformed."

"The proteins in skin most prone to glycation are the same ones that make a youthful complexion so plump and springy—collagen and elastin. When those proteins hook up with renegade sugars, they become discolored, weak, and less supple; this shows up on the skin's surface as wrinkles, sagginess, and a loss of radiance. The presence of AGEs also makes the complexion more vulnerable to bad-news assailants such as UV light and cigarette smoke. As New York–based dermatologist Cheryl Karcher, MD, puts it: "Number one, the glucose makes the cells abnormal; and number two, it creates free radicals. So you get a double whammy when it comes to aging."

"The external signs of glycation show up around the age of 30 or 35, when a perfect storm of built-up sun damage, environmental oxidative stress, hormonal changes, and the development of AGEs begins to result in, well, a-g-e. "When you're younger, your body has more resources to ward off damage, and you're producing more collagen," says New York– and Miami-based dermatologist Fredric Brandt, MD, who in 2007 was one of the first to launch an anti-aging skin-care line specifically addressing glycation. "When you reach a certain age, these sugar by-products begin to build up at the same time that your threshold for damage is getting lower."

Insulin and Its Metabolic Effects(2001)
Glycation
http://articles.mercola.com/sites/articles/archive/2001/07/14/insulin-part-one.aspx
"Everyone knows that oxygen causes damage, but unfortunately the press has not been as kind to publicize glycation. Glycation is the same as oxidation except substitute the word glucose. When you glycate something you combine it with glucose. Glucose combines with anything else really; it's a very sticky molecule.

Just take sugar on your fingers. It's very sticky. It sticks specifically to proteins. So the glycation of proteins is extremely important. If it sticks around a while it produces what are called advanced glycated end products (A.G.E.s).

That acronym is not an accident. If you can turn over, or re-manufacture, the protein that's good, and it increases the rate of protein turnover if you are lucky. Glycation damages the protein to the extent that white blood cells will come around and gobble it up and get rid of it, so then you have to produce more, putting more of a strain on your ability to repair and maintain your body.

That is the best alternative; the worst alternative is when those proteins get glycated that can't turn over very rapidly, like collagen, or like a protein that makes up nerve tissue. These proteins cannot be gotten rid of, so the protein accumulates, and the A.G.E.s accumulate and continue to damage.

That includes the collagen that makes up the matrix of your arteries. A.G.E.s are so bad that we know that there are receptors for A.G.E.s, hundreds of receptors, for every macrophage."